Lipocalin 2 Diminishes Invasiveness and Metastasis of Ras-transformed Cells
نویسندگان
چکیده
منابع مشابه
Lipocalin 2 diminishes invasiveness and metastasis of Ras-transformed cells.
Lipocalin 2, an iron-siderophore-binding protein, converts embryonic kidney mesenchyme to epithelia. We found that lipocalin 2 could also convert 4T1-Ras-transformed mesenchymal tumor cells to an epithelial phenotype, increase E-cadherin expression, and suppress cell invasiveness in vitro and tumor growth and lung metastases in vivo. The Ras-MAPK pathway mediated the epithelial to mesenchymal t...
متن کاملLipocalin 2 antagonizes the proangiogenic action of ras in transformed cells.
Lipocalin 2 is an iron-binding secreted protein that converts embryonic kidney mesenchyme to epithelia. Previously, we reported that lipocalin 2 could revert 4T1-ras-transformed mesenchymal tumor cells to a more epithelial phenotype, increase E-cadherin expression, and suppress cell invasiveness in vitro and in vivo, indicating that lipocalin 2 is a metastasis suppressor. Here, we show that lip...
متن کاملLipocalin 2 promotes lung metastasis of murine breast cancer cells
BACKGROUND Lipocalin 2, an iron binding protein, is abnormally expressed in some malignant human cancers and may play an important role in tumor metastasis. However, the roles of lipocalin 2 in breast cancer formation and metastasis have not been clearly shown. This study aimed to investigate the roles of lipocalin 2 in breast tumor metastasis. METHODS Lipocalin 2 was overexpressed in the met...
متن کاملOncogenic Phenotypes in K-Ras Transformed Cells
Genetic mutations in K-Ras, an oncogene belonging to the Ras protein superfamily, are present in number of cancers, including over 90% of pancreatic and 50% of colorectal cancers. The mutated or oncogenic form of the K-Ras GTPase is perpetually locked in the GTP-bound active conformation, thereby inducing extreme and rapid cell proliferation as well as decreasing cell sensitivity to suspension-...
متن کاملInhibition of lipocalin 2 impairs breast tumorigenesis and metastasis.
Lipocalin 2 (LCN2; also known as NGAL) is a secreted glycoprotein and its elevated expression has been observed in breast cancers. However, the importance of LCN2 in breast tumorigenesis is unclear. Here, we employed a spontaneous mammary tumor mouse model showing that MMTV-ErbB2(V664E) mice lacking mouse LCN2 had significantly delayed mammary tumor formation and metastasis with reduced matrix ...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2005
ISSN: 0021-9258
DOI: 10.1074/jbc.m413047200